Volume 3, Issue 1 (Winter-Spring 2020)                   Mod Med Lab J 2020, 3(1): 46-59 | Back to browse issues page

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Belali Kharaji M, Yadegari M, Hosseini Sharif abad M, Anvari M, Abbasi Sarcheshmeh A, Dortaj H. Stereological Study on the Effects of Maternal Caffeine Consumption on Histomorphometric Changes of Testis and Prostate in Rat Offspring. Mod Med Lab J 2020; 3 (1) :46-59
URL: http://modernmedlab.com/article-1-68-en.html
Abstract:   (3106 Views)
Background and Objective: It is conceivable that caffeine consumption would induce gonadal changes. The aim of this study is to assess the impact of embryonic caffeine exposure on rat testis and prostate.
Materials and Methods: Female rats were divided into (n=7): A control, only received drinking water. B and C groups received caffeine low dose (26 mg/kg) and high dose (45 mg/kg) respectively via drinking water during pregnancy and lactation. Structural changes in testis and prostate were studied by using stereological methods at 21, 60 and120 days of postnatal development.
Results: Our result showed decreases in body and testis weight of offspring of group C compared to other groups at all ages (P< 0.05). The Testis volume showed significant differences between the offspring of both experimental groups and control at days 21, 60 and 120 (P<0.05). There were significant differences in the number of sperm cells of offspring of experimental groups compared to the control group in different ages (P<0.05). The number of sertoli, spermatocyte and spermatid cells of offspring in group C showed a significant decrease compared with other groups at all days (P<0.01). The number of spermatogonia cells in group C offspring showed a significant decrease compared to the control group at different days (P<0.05). The mean Johnsen score decreased in offspring of group C compared to the control group (P<0.05).
Conclusion: Results showed that maternal caffeine consumption altered the structure of testis and prostate gland and spermatogenesis of offspring in adulthood
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Type of Study: Original | Subject: Laboratory Methods

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