Volume 2, Issue 1 (Winter-Spring 2019)
Mod Med Lab J 2019, 2(1): 107-109 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Heydari Z, Vosough M. New Platforms For Drug Screening And Toxicology: Necessity Or Need?. Mod Med Lab J 2019; 2 (1) :107-109
URL: http://modernmedlab.com/article-1-57-en.html
URL: http://modernmedlab.com/article-1-57-en.html
Abstract: (8176 Views)
The liver is the largest internal organ in the human body that is responsible for more than 500 vital functions, including biosynthesis of major plasma proteins, immunity against infectious pathogens, balancing energy metabolism and xenobiotics biotransformation (1). One of the main functions of the liver is an important role in drug metabolism (2). Since developing new drug compounds into market have faced many challenges such as safety, efficacy and high costs as well, using preclinical drug screening tests are necessary to eliminate false leads (3). Therefore, availability of a suitable and convenient model is crucial to predict drug toxicity.
Type of Study: Brief Original Article |
Subject:
Clinical Microbiology
References
1. Gissen P, Arias IM. Structural and functional hepatocyte polarity and liver disease. Journal of hepatology. 2015 Oct 31; 63(4):1023-37. [DOI:10.1016/j.jhep.2015.06.015] [PMID] [PMCID]
2. Levy G, Bomze D, Heinz S, Ramachandran SD, Noerenberg A, Cohen M, Shibolet O, Sklan E, Braspenning J, Nahmias Y. Long-term culture and expansion of primary human hepatocytes. Nature biotechnology. 2015 Dec 1; 33(12):1264-71. [DOI:10.1038/nbt.3377] [PMID]
3. Yan S, Wei J, Liu Y, Zhang H, Chen J, Li X. Hepatocyte spheroid culture on fibrous scaffolds with grafted functional ligands as an in vitro model for predicting drug metabolism and hepatotoxicity. Acta biomaterialia. 2015 Dec 31; 28:138-48. [DOI:10.1016/j.actbio.2015.09.027] [PMID]
4. Martignoni M, Groothuis GM, de Kanter R. Species differences between mouse, rat, dog, monkey and human CYP-mediated drug metabolism, inhibition and induction. Expert opinion on drug metabolism & toxicology. 2006 Dec 1;2(6):875-94. [DOI:10.1517/17425255.2.6.875] [PMID]
5. Szkolnicka D, Farnworth SL, Lucendo-Villarin B, Storck C, Zhou W, Iredale JP, Flint O, Hay DC. Accurate prediction of drug‐induced liver injury using stem cell‐derived populations. Stem cells translational medicine. 2014 Feb 1;3(2):141-8. [DOI:10.5966/sctm.2013-0146] [PMID] [PMCID]
6. Guillouzo A, Corlu A, Aninat C, Glaise D, Morel F, Guguen-Guillouzo C. The human hepatoma HepaRG cells: a highly differentiated model for studies of liver metabolism and toxicity of xenobiotics. Chemico-biological interactions. 2007 May 20;168(1):66-73. [DOI:10.1016/j.cbi.2006.12.003] [PMID]
7. Bell CC, Lauschke VM, Vorrink SU, Palmgren H, Duffin R, Andersson TB, Ingelman-Sundberg M. Transcriptional, Functional, and Mechanistic Comparisons of Stem Cell–Derived Hepatocytes, HepaRG Cells, and Three-Dimensional Human Hepatocyte Spheroids as Predictive In Vitro Systems for Drug-Induced Liver Injury. Drug Metabolism and Disposition. 2017 Apr 1;45(4):419-29. [DOI:10.1124/dmd.116.074369] [PMID] [PMCID]
8. Zeilinger K, Freyer N, Damm G, Seehofer D, Knöspel F. Cell sources for in vitro human liver cell culture models. Experimental Biology and Medicine. 2016 Sep;241(15):1684-98. [DOI:10.1177/1535370216657448] [PMID] [PMCID]
9. Bell CC, Hendriks DF, Moro SM, Ellis E, Walsh J, Renblom A, Puigvert LF, Dankers AC, Jacobs F, Snoeys J, Sison-Young RL. Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease. Scientific reports. 2016 May 4;6:25187. [DOI:10.1038/srep25187] [PMID] [PMCID]
10. Bonn B, Svanberg P, Janefeldt A, Hultman I, Grime K. Determination of human hepatocyte intrinsic clearance for slowly metabolized compounds: comparison of a primary hepatocyte/stromal cell co-culture with plated primary hepatocytes and HepaRG. Drug Metabolism and Disposition. 2016 Apr 1;44(4):527-33. [DOI:10.1124/dmd.115.067769] [PMID]
11. Ramachandran SD, Schirmer K, Münst B, Heinz S, Ghafoory S, Wölfl S, Simon-Keller K, Marx A, Øie CI, Ebert MP, Walles H. In vitro generation of functional liver organoid-like structures using adult human cells. PloS one. 2015 Oct 21;10(10):e0139345. [DOI:10.1371/journal.pone.0139345] [PMID] [PMCID]
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
