Volume 2, Issue 1 (Winter-Spring 2019)                   Mod Med Lab J 2019, 2(1): 91-95 | Back to browse issues page

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Zinatizadeh M R, Masoumalinejad Z, Parnak F. The prevalence of Mycoplasma hyorhinis contamination in tissues samples from cancer patients: A Brief Report. Mod Med Lab J 2019; 2 (1) :91-95
URL: http://modernmedlab.com/article-1-52-en.html
Abstract:   (5760 Views)
Infectious agents cause 15-20% of cancers worldwide. The infectious agents and contamination may be caused by a local chronic and advanced local inflammatory response, or by tumorization. Mycoplasma contamination can interfere with biological agents and cause DNA damage which affects gene expression, and disrupts the control of cell cycle inspection and apoptotic responses. Mycoplasmas are widely distributed in nature; some mycoplasmas have the ability to penetrate into the cell and cause severe disease. Most mycoplasmas are known to infect the cell culture media, which is difficult to detect and contaminate. M. hyorhinis is one of the causes of Mycoplasma contamination in tissues samples from cancer patients. Mycoplasma is related with human cancers and several other human diseases. Several studies have shown that the potential role of M. hyorhinis includes esophageal, gastric, lung, breast, glioma, colon, and prostate cancers. The prevalence of M hyorhinis in various tissues leads to cancer progression. Therefore, it is necessary to pay more attention to this mycoplasma agent in order to control and understand its mechanism.
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Type of Study: Brief Original Article | Subject: Clinical Microbiology

1. Jemal A, Siegel R, Ward E, Murray T, Xu J, Thun MJ: Cancer statistics, 2007. CA Cancer J Clin 2007, 57:43-66. [DOI:10.3322/canjclin.57.1.43] [PMID]
2. Zinatizadeh MR. 2016. "Health Monitoring of Laboratory NIH Mice produced in Razi Institute Karaj to Mycoplasma Muris agent" M.Sc dissertation, University of Tonekabon.
3. Koraitim MM, Metwalli NE, Atta MA, el-Sadr AA: Changing age incidence and pathological types of schistosoma-associated bladder carcinoma. J Urol 1995, 154:1714-6. [DOI:10.1016/S0022-5347(01)66763-6]
4. Hanto DW, Frizzera G, Gajl-Peczalska KJ, Sakamoto K, Purtilo DT, Balfour HH Jr,Simmons RL, Najarian JS: Epstein-Barr virus induced B cell lymphoma after renal transplantation. Acyclovir therapy and transition from polyclonal to monoclonal B-cell proliferation. NEJM 1982, 306:913-8. [DOI:10.1056/NEJM198204153061506] [PMID]
5. Reeves WC, Brinton LA, Garcia M, Brenes MM, Herrero R, Gaitan E, Tenorio F, de Britton RC, Rawls WE: Human papillomavirus infection and cervical cancer in Latin America. NEJM 1989, 320:1437-41. [DOI:10.1056/NEJM198906013202201] [PMID]
6. Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM: Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 2008, 2010(127):2893–2917.
7. Drexler HG, Uphoff CC, Dirks W, Macleod RAF: Mix-ups and mycoplasma: the enemies within. Leuk Res 2002, 26:329-333. [DOI:10.1016/S0145-2126(01)00136-9]
8. Drexler HG, Uphoff CC: Mycoplasma contamination of cell cultures: incidence, sources, effects, detection, elimination, prevention. Cytotechnology 2002, 39:23-38. [DOI:10.1023/A:1022913015916] [PMID] [PMCID]
9. Sun G, Xu X, Wang Y, Shen X, Chen Z, Yang J, et al. Mycoplasma pneumoniae Infection Induces Reactive Oxygen Species and DNA Damage in A549 Human Lung Carcinoma Cells. Infect Immun. 2008; 76:4405–13. doi: 10.1128/IAI.00575-08 PMID: 18663006 [DOI:10.1128/IAI.00575-08]
10. Namiki K, Goodson S, Porvasnik S, Allan RW, Iczkowski KA, Urbanek C, et al. Persistent Exposure to Mycoplasma Induces Malignant Transformation of Human Prostate Cells. PLoS One. 2009; 4:e6872. doi: 10.1371/journal.pone.0006872 PMID: 19721714 [DOI:10.1371/journal.pone.0006872]
11. Rogers MB. Mycoplasma and cancer: in search of the link. Oncotarget. 2011; 2:271–3. PMID:21508438. [DOI:10.18632/oncotarget.264] [PMID] [PMCID]
12. Cazanave C, Manhart LE, Bebear C. Mycoplasma genitalium, an emerging sexually transmitted pathogen. Med Mal Infect. 2012; 42:381–92. doi: 10.1016/j.medmal.2012.05.006 PMID: 22975074 [DOI:10.1016/j.medmal.2012.05.006]
13. Chrisment D, Charron A, Cazanave C, Pereyre S, Bébéar C. Detection of macrolide resistance in Mycoplasma genitalium in France. J Antimicrob Chemother. 2012; 67:2598–601. doi: 10.1093/jac/ dks263 PMID: 22773740
14. Roediger WE. Intestinal mycoplasma in Crohn's disease. Novartis Found Symp. 2004; 263:85–93. PMID: 15669636 [DOI:10.1002/0470090480.ch7]
15. Paton GR, Jacobs JP, Perkins FT: Chromosome changes in human diploid-cell cultures infected with Mycoplasma. Nature 1965, 207:43–45. [DOI:10.1038/207043a0] [PMID]
16. Huang S, Li JY, Wu J, Meng L, Shou CC. Mycoplasma infections and different human carcinomas. World J Gastroenterol2001; 7:266-269. [DOI:10.3748/wjg.v7.i2.266] [PMID] [PMCID]
17. Yang H, Qu L, Ma H, Chen L, Liu W, Liu C, et al. Mycoplasma hyorhinis infection in gastric carcinoma and its effects on the malignant phenotypes of gastric cancer cells. BMC Gastroenterol 2010;10:132. [DOI:10.1186/1471-230X-10-132] [PMID] [PMCID]
18. Kornspan JD, Tarshis M, Rottem S. Invasion of melanoma cells by Mycoplasma hyorhinis: enhancement by protease treatment. Infect Immun 2010;78:611-617. [DOI:10.1128/IAI.01017-09] [PMID] [PMCID]
19. Dong ZW, Wan WH, Li ZP, Qiu WR, Wei SM. A monoclonal antibodies PD4 against gastric cancer cell line MGC803.ShengwuHuaxueZazhi 1985;1:52-58.
20. Ning JY, Sun GX, Huang S, Ma H, An P, Meng L, et al. Identification of antigens by monoclonal antibody PD4 and its expression in Escherichia coli. World J Gastroenterol 2003;9:2164-2168. [DOI:10.3748/wjg.v9.i10.2164] [PMID] [PMCID]
21. Sippel KH, Robbins AH, Reutzel R, Boehlein SK, Namiki K, Goodison S, Agbandje-McKenna M, Rosser CJ, McKenna R: Structural insights into the extracytoplasmic thiamine-binding lipoprotein p37 of Mycoplasma hyorhinis. J Bacteriol 2009, 191:2585–2592. [DOI:10.1128/JB.01680-08] [PMID] [PMCID]
22. Urbanek C, Goodison S, Chang M, Porvasnik S, Sakamoto N, Li CZ, et al. Detection of antibodies directed atM. hyorhinis p37 in the serum of men with newly diagnosed prostate cancer. BMC Cancer. 2011; 11:233. doi: 10.1186/1471-2407-11-233 PMID: 21663671 [DOI:10.1186/1471-2407-11-233]
23. Duan H, Chen L, Qu L, Yang H, Song SW, Han Y, et al. Mycoplasma hyorhinis infection promotes NFkB- dependent migration of gastric cancer cells. Cancer Res. 2014; 74:5782–94. doi: 10.1158/0008-5472.CAN-14-0650 PMID: 25136068 [DOI:10.1158/0008-5472.CAN-14-0650]
24. Gong M, Meng L, Jiang B, Zhang J, Yang H, Wu J, Shou C: p37 from Mycoplasma hyorhinis promotes cancer cell invasiveness and metastasis through activation of MMP-2 and followed by phosphorylation of EGFR. Mol Cancer Ther 2008, 7:530–537. [DOI:10.1158/1535-7163.MCT-07-2191] [PMID]
25. Sasaki Y, Blanchard A, Watson HL, Garcia S, Dulioust A, Montagnier L, Gougeon ML. In vitro influence of Mycoplasma penetrans on activation of peripheral T lymphocytes from healthy donors or human immunodeficiency virus-infected individuals. Infection and immunity. 1995 Nov 1;63(11):4277-83. [PMID] [PMCID]
26. Mariotti E, Gemei M, Mirabelli P, D'Alessio F, Di Noto R, Fortunato G, Del Vecchio L. The percentage of CD133+ cells in human colorectal cancer cell lines is influenced by Mycoplasma hyorhinis infection. BMC cancer. 2010 Mar 30;10(1):120. [DOI:10.1186/1471-2407-10-120] [PMID] [PMCID]
27. Barykova YA, Logunov DY, Shmarov MM, Vinarov AZ, Fiev DN, Vinarova NA, Rakovskaya IV, Baker PS, Shyshynova I, Stephenson AJ, Klein EA. Association of Mycoplasma hominis infection with prostate cancer. Oncotarget. 2011 Apr 4;2(4):289-97. [DOI:10.18632/oncotarget.256] [PMID] [PMCID]

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