Volume 6, Issue 2 (Summer-Fall 2023)
Mod Med Lab J 2023, 6(2): 39-46 |
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Neishaboori H, Choubchian A A, Tamimi F. Relationship between Liver Function Tests Levels with Degree of FibroScan Test in non-alcoholic Fatty Liver Disease. Mod Med Lab J 2023; 6 (2) :39-46
URL: http://modernmedlab.com/article-1-139-en.html
URL: http://modernmedlab.com/article-1-139-en.html
Abstract: (192 Views)
Background and Objectives: Non-Alcoholic Fatty Liver Disease (NAFLD) occurs when liver fat content exceeds 5-10%. The initial stage is simple fatty liver, which can progress to alcoholic steatohepatitis and ultimately lead to cirrhosis of the liver. The first step in treatment is a weight loss diet.
Methods: In this study, patients with non-alcoholic fatty liver disease who had undergone all necessary tests to rule out other causes of liver involvement, such as viral and autoimmune hepatitis and Wilson's disease, were evaluated. These patients were approved by a gastroenterologist and underwent a FibroScan over a six-month period to assess their condition. The initial checklist included demographic information (height and weight), blood pressure, history of alcohol consumption, and liver enzyme levels.
Results: Among 86 participants, 25 (29.1%) had Grade 0 fatty liver, 39 (54.7%) had Grade 1, 14 (11.6%) had Grade 2, and 8 (4.7%) had Grade 3 fatty liver. Additionally, 8 patients had anemia, 3 (2.5%) had elevated bilirubin levels, 3 (2.5%) had iron deficiency, and only 1 patient had liver issues related to an autoimmune problem or specific disease. There was no significant relationship between the FibroScan score and enzyme levels in any gender.
Conclusion: The prevalence of non-alcoholic fatty liver disease is higher in women than in men, and liver enzymes do not accurately reflect the degree of liver fibrosis. It is recommended that imaging methods, especially FibroScan, be used instead of routine enzyme level measurements to assess liver tissue conditions.
Methods: In this study, patients with non-alcoholic fatty liver disease who had undergone all necessary tests to rule out other causes of liver involvement, such as viral and autoimmune hepatitis and Wilson's disease, were evaluated. These patients were approved by a gastroenterologist and underwent a FibroScan over a six-month period to assess their condition. The initial checklist included demographic information (height and weight), blood pressure, history of alcohol consumption, and liver enzyme levels.
Results: Among 86 participants, 25 (29.1%) had Grade 0 fatty liver, 39 (54.7%) had Grade 1, 14 (11.6%) had Grade 2, and 8 (4.7%) had Grade 3 fatty liver. Additionally, 8 patients had anemia, 3 (2.5%) had elevated bilirubin levels, 3 (2.5%) had iron deficiency, and only 1 patient had liver issues related to an autoimmune problem or specific disease. There was no significant relationship between the FibroScan score and enzyme levels in any gender.
Conclusion: The prevalence of non-alcoholic fatty liver disease is higher in women than in men, and liver enzymes do not accurately reflect the degree of liver fibrosis. It is recommended that imaging methods, especially FibroScan, be used instead of routine enzyme level measurements to assess liver tissue conditions.
Type of Study: Original Research Article |
Subject:
Medical Sciences
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