Volume 6, Issue 2 (4-2023)                   Mod Med Lab J 2023, 6(2): 24-28 | Back to browse issues page

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Maharjan S, Thakur C, Tazia R, Mainali S. Interference of cold agglutinin with RBC parameters in a non-hemolytic case. Mod Med Lab J 2023; 6 (2) :24-28
URL: http://modernmedlab.com/article-1-141-en.html
Abstract:   (69 Views)
Background: Cold agglutinin disease is a rare condition affecting 1 per million population annually. It is usually associated with hemolytic anemia. We report a case of interference of cold agglutinin with red blood cell (RBC) parameters in a non-hemolytic case.
Case: A 31-year-old male presented with complaints of a cough and fever. Routine blood investigation revealed normal hemoglobin with low RBC, packed cell volume (PCV), high mean corpuscular volume (MCH), and mean corpuscular hemoglobin concentration (MCHC). The indirect Coombs test was negative. So, interference due to cold agglutinin was suspected, which was confirmed following the disappearance of agglutinin after incubation at 37° C for 30 minutes.
Conclusion: The possibility of RBC cold agglutinin should be suspected if there is any mismatch between RBC parameters and appropriate measures should be taken for proper delivery of results.

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Type of Study: Case report Article | Subject: Hematology

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