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Showing 2 results for Inflammation

Mohammadreza Abdollahzadeh Estakhri, Parviz Kavakeb, Delaram Fathi, Gholamreza Karimi, Amirhosein Mohammadpour, Maryam Rahbar,
Volume 1, Issue 1 (1-2018)
Abstract

Background and Objective: Beta-2 Microglobulin (β2M) is a middle molecular weight uremic toxin. Lack of β2M removal leads to β2M accumulation and amyloidosis in hemodialysis patients. The present research aims to determine the relationship between β2M and inflammatory factors, such as C-reactive protein (CRP), albumin, and high-density lipoprotein (HDL) in hemodialysis patients. 

Methods: Fifty-four hemodialysis patients were selected and their pre- and post-dialysis serum levels of β2M, CRP, albumin, and HDL, were measured.

Results: There was an obvious inverse relationship between β2M level and serum level of albumin, while no relationship was found between β2M and CRP or HDL.

Conclusion: According to the findings of this study, it was identified that inflammatory-induced increase in β2M level in dialysis patients leads to reduced serum albumin


Erfan Mohammadi Sepahvand, Mina Masoudnia, Haniyeh Sadat Hosseininia, Alireza Kazempour, Nazila Bostanshirin, Arsalan Jalili, Amin Ebrahimi Sadrabadi,
Volume 4, Issue 1 (1-2021)
Abstract

Over the recent years, studies in the area of cancer microenvironment and the cellular groups existing in this environment have indicated the significant role of them in progression of cancer studies. Among the mentioned cellular groups, as the main inflammatory components of stroma, Tumor associate macrophage (TAM) cells have the capacity of affecting the cancer tissue in different aspects. With their plasticity capacity, macrophages can change into M1 (classic) or M2 (alternative) macrophage reacting to different signals.  In the tumor environment, they usually change into the M2 phenotype, and this phenotype can create a precancerous role in the macrophage and facilitate the invasion of tumor cells and metastasis, angiogenesis, remodeling of the extracellular matrix, and suppression of the immune system. The various roles of these cells and their reversibility have made the TAMs a potential target of the cancer treatment. This process takes place by different mechanisms such as Interference with TAMs survival, Inhibition of macrophage recruitment, repolarization of M2-like TAMs towards an M1-like phenotype, nano particle and liposome-based drug delivery system. This review study investigates the markers and the function of M1, M2, and tumor-associated macrophages, and finally, it proposes the latest clinical and laboratory approach for targeting the TAMs.  

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