Dr Atena Tamimi, Dr Sepehr Olangian-Tehrani, Dr Narjes Sadat Farizani Gohari, Dr Sadaf Parvin, Dr Arash Khosravi, Dr Zahra Khanjani, Dr Kiana Kimiaei Asadi, Dr Seyede Fateme Saeidi Nasab, Dr Kasra Moeinabadi-Bidgoli, Dr Massoud Vosough,
Volume 6, Issue 2 (Summer-Fall 2023)
Abstract
Colectomy is an invasive procedure indicated for various colon diseases. Surgical resection of the colon potentially affects glucose metabolism. The intestine secrets different hormones during digestion and controls absorption and metabolism of nutrients. There are gut-associated factors involved in glucose homeostasis. These include incretins, cholecystokinin, short-chain fatty acids, and non-esterified fatty acids. Type 2 diabetes mellitus (T2DM) is a major health problem with a constantly and dramatically increasing incidence and prevalence. In this review, the role of colon secretions and their cross-talk with gut microbiota in glucose metabolism and the pathophysiological aspects of alterations in bacterial endotoxin level, bile acid metabolism, and gut hormone secretion were highlighted. We have also noted the potential complications of colectomy in terms of glucose metabolism and homeostasis. All the clinical findings in previous studies documenting the association between T2DM post-colectomy were included as well.
