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The Cytotoxic Effects of Eggplant Peel Extract on Human Gastric Adenocarcinoma Cells and Normal Cells
Fatemeh Afshari, Hoda Seraj, Zahra Sadat Hashemi, Marziyeh Timajchi, Olamafar Ensiyeh, Ghotbi Ladan, Masoomeh Asadi, Zahra Elyasi, Meysam Ganjibakhsh,
Volume 1, Issue 2 (Summer-Fall 2018)
Abstract

Background and objective: Gastric cancer is the fourth common and the second deadliest cancer worldwide, which the major causes of its prevalence are genetic factors and the lifestyle, such as eating fast foods, physical inactivity, environmental pollution, and other natural factors.

Method: This research was performed in human and animal cell bank of Iranian Biological Resource Center, and cytotoxic effects of the eggplant peel extract was investigated on human gastric cancer cells and normal cells. During this experiment, all quality control procedures were performed on cell lines, including bacteria, fungi, yeasts, molds, mycoplasma, as well as HIV-I, HBV, HCV, EBV viruses, and the results of negative tests were reported. MTT test was used to determine the cytotoxicity of this substance and the IC50 value.

Resutls: The results indicated that the toxic effect of eggplant extract was more on the cancer cells compared to the normal cells and it is notable that, the death rate of the cancer cells in three concentrations showed a significant difference compared to the normal cells. 

Conclusion: From the results of this study, it is recommended that further investigations be conducted on eggplant extract as an anticancer nutrient.


Association of Type 2 Diabetes with Colectomy; True or False?
Dr Atena Tamimi, Dr Sepehr Olangian-Tehrani, Dr Narjes Sadat Farizani Gohari, Dr Sadaf Parvin, Dr Arash Khosravi, Dr Zahra Khanjani, Dr Kiana Kimiaei Asadi, Dr Seyede Fateme Saeidi Nasab, Dr Kasra Moeinabadi-Bidgoli, Dr Massoud Vosough,
Volume 6, Issue 2 (Summer-Fall 2023)
Abstract
Colectomy is an invasive procedure indicated for various colon diseases.  Surgical resection of the colon potentially affects glucose metabolism. The intestine secrets different hormones during digestion and controls absorption and metabolism of nutrients. There are gut-associated factors involved in glucose homeostasis. These include incretins, cholecystokinin, short-chain fatty acids, and non-esterified fatty acids. Type 2 diabetes mellitus (T2DM) is a major health problem with a constantly and dramatically increasing incidence and prevalence. In this review, the role of colon secretions and their cross-talk with gut microbiota in glucose metabolism and the pathophysiological aspects of alterations in bacterial endotoxin level, bile acid metabolism, and gut hormone secretion were highlighted. We have also noted the potential complications of colectomy in terms of glucose metabolism and homeostasis. All the clinical findings in previous studies documenting the association between T2DM post-colectomy were included as well.
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