en ایمنی شناسی Immunology مقاله مروری Review Article Over the recent years, studies in the area of cancer microenvironment and the cellular groups existing in this environment have indicated the significant role of them in progression of cancer studies. Among the mentioned cellular groups, as the main inflammatory components of stroma, Tumor associate macrophage (TAM) cells have the capacity of affecting the cancer tissue in different aspects. With their plasticity capacity, macrophages can change into M1 (classic) or M2 (alternative) macrophage reacting to different signals.  In the tumor environment, they usually change into the M2 phenotype, and this phenotype can create a precancerous role in the macrophage and facilitate the invasion of tumor cells and metastasis, angiogenesis, remodeling of the extracellular matrix, and suppression of the immune system. The various roles of these cells and their reversibility have made the TAMs a potential target of the cancer treatment. This process takes place by different mechanisms such as Interference with TAMs survival, Inhibition of macrophage recruitment, repolarization of M2-like TAMs towards an M1-like phenotype, nano particle and liposome-based drug delivery system. This review study investigates the markers and the function of M1, M2, and tumor-associated macrophages, and finally, it proposes the latest clinical and laboratory approach for targeting the TAMs.   tumor associated macrophage, inflammation, angiogenesis, immunosuppression, TAM-based therapy 52 67 http://modernmedlab.com/browse.php?a_code=A-10-73-3&slc_lang=en&sid=1 Erfan Mohammadi Sepahvand erfan.msepah94@gmail.com 10031947532846001517 10031947532846001517 No Faculty of Veterinary Medicine, Karaj Branch, Islamic Azad University, Karaj, Iran Mina Masoudnia masoudnia.mina@yahoo.com 10031947532846001518 10031947532846001518 No Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Haniyeh Sadat Hosseininia hanahosseininia75@gmail.com 10031947532846001519 10031947532846001519 No Department of Cellular and Molecular Biology, Faculty of Advanced Medical Science, Tehran Islamic Azad University of Medical Sciences, Tehran, Iran Alireza Kazempour ali42153@gmail.com 10031947532846001520 10031947532846001520 No Department of Microbiology, Faculty of Science, Lahijan Branch, Islamic Azad University, Lahijan, Iran Nazila Bostanshirin n.bostan@abzums.ac.ir 10031947532846001521 10031947532846001521 No Department of Microbiology, School of Medicine Science, Alborz University of Medical Science, Alborz, Iran Arsalan Jalili Jalili.arsalan@royaninstitute.org 10031947532846001522 10031947532846001522 Yes Hematopoietic Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran Amin Ebrahimi Sadrabadi Amin.ebrahimi@royaninstitute.org 10031947532846001523 10031947532846001523 No Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACER, Tehran, Iran.