other میکروب شناسی بالینی Clinical Microbiology مقاله کوتاه پژوهشی Brief Original Article The liver is the largest internal organ in the human body that is responsible for more than 500 vital functions, including biosynthesis of major plasma proteins, immunity against infectious pathogens, balancing energy metabolism and xenobiotics biotransformation (1). One of the main functions of the liver is an important role in drug metabolism (2). Since developing new drug compounds into market have faced many challenges such as safety, efficacy and high costs as well, using preclinical drug screening tests are necessary to eliminate false leads (3). Therefore, availability of a suitable and convenient model is crucial to predict drug toxicity. Hepatocyte, Drug toxicity, Cytochrome p450, 3D culture, organoids 107 109 http://modernmedlab.com/browse.php?a_code=A-10-2-1&slc_lang=other&sid=1 Zahra Heydari 10031947532846001616 10031947532846001616 No Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran Massoud Vosough masvos@royaninstitute.org 10031947532846001617 10031947532846001617 Yes Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran