Modern Medical Laboratory Journal
Mod Med Lab J
Medical Sciences
http://modernmedlab.com
1
admin
2371-770X
2371-770X
10.30699/mmlj17
en
jalali
1396
10
1
gregorian
2018
1
1
1
1
online
1
fulltext
en
An Investigation of the Relationship between Beta-2 Microglobulin (β2M) and Inflammatory Factors (Serum Levels of CRP and Albumin) and High Density Lipoproteins (HDL) in Hemodialysis Patients
روش های تشخیص آزمایشگاهی
Laboratory Methods
مقاله پژوهشی
Original Research Article
<p dir="ltr" style="text-align: justify"><strong>Background and Objective:</strong> Beta-2 Microglobulin (β2M) is a middle molecular weight uremic toxin. Lack of β2M removal leads to β2M accumulation and amyloidosis in hemodialysis patients. The present research aims to determine the relationship between β2M and inflammatory factors, such as C-reactive protein (CRP), albumin, and high-density lipoprotein (HDL) in hemodialysis patients. </p>
<p dir="ltr" style="text-align: justify"><strong>Methods:</strong> Fifty-four hemodialysis patients were selected and their pre- and post-dialysis serum levels of β2M, CRP, albumin, and HDL, were measured.</p>
<p dir="ltr" style="text-align: justify"><strong>Results:</strong> There was an obvious inverse relationship between β2M level and serum level of albumin, while no relationship was found between β2M and CRP or HDL.</p>
<p dir="ltr" style="text-align: justify"><strong>Conclusion:</strong> According to the findings of this study, it was identified that inflammatory-induced increase in β2M level in dialysis patients leads to reduced serum albumin</p>
<p dir="ltr" style="text-align: justify"></p>
Beta-2 Microglobulin, albumin, hemodialysis, inflammation.
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http://modernmedlab.com/browse.php?a_code=A-10-1-18&slc_lang=en&sid=1
Mohammadreza
Abdollahzadeh Estakhri
10031947532846001558
10031947532846001558
Yes
Sina Hospital, Tehran University of Medical Science, Tehran, Iran.
Parviz
Kavakeb
10031947532846001559
10031947532846001559
No
Sina Hospital, Tehran University of Medical Science, Tehran, Iran.
Delaram
Fathi
10031947532846001560
10031947532846001560
No
Department of Technical and Vocational Organization, Karaj University, Karaj, Iran
Gholamreza
Karimi
10031947532846001561
10031947532846001561
No
Faculty of Pharmacy, Mashhad University of Medical Science, Mashhad, Iran
Amirhosein
Mohammadpour
10031947532846001562
10031947532846001562
No
Faculty of Pharmacy, Mashhad University of Medical Science, Mashhad, Iran
Maryam
Rahbar
10031947532846001563
10031947532846001563
No
Sina Hospital, Tehran University of Medical Science, Tehran, Iran.