en سلول های بنیادی و پزشکی بازساختی Stem Cell and Regenerative Medicine مقاله مروری Review Article <span style="font-size:11pt"><span style="line-height:normal"><span style="font-family:Calibri,sans-serif"><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Azoospermia, characterized by the absence of sperm in semen, poses a significant challenge to male fertility. Mesenchymal stromal/stem cell (MSC) therapy has emerged as a promising approach for treating azoospermia by promoting spermatogenesis and restoring fertility. MSCs possess the ability to differentiate into male germ cells and create a favorable microenvironment for spermatogenesis through the secretion of growth factors and cytokines. Preclinical studies have shown encouraging results, with improved testicular histology, sperm production, and fertility outcomes in animal models of azoospermia. Limited clinical studies in humans have also demonstrated the potential of MSC therapy in restoring spermatogenesis. However, challenges such as standardization of MSC isolation, characterization, and administration protocols, as well as the need for long-term safety and efficacy data, remain to be addressed. Despite these challenges, MSC therapy holds great promise for the treatment of azoospermia and warrants further research to optimize its use in clinical practice.</span></span></span></span></span><br> &nbsp; ,Azoospermia,Mesenchymal Stem Cell Transplantation,Spermatogenesis,Male Infertility,Testicular Diseases 8 12 http://modernmedlab.com/browse.php?a_code=A-10-916-1&slc_lang=en&sid=1 Farhad Rahmanifar f.rahmanifar@yahoo.com 10031947532846002155 10031947532846002155 Yes Department of Basic Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran Nadiar Mussin nadiar_musin@zkmu.kz 10031947532846002156 10031947532846002156 No General Surgery, West-Kazakhstan Medical University named after Marat Ospanov, Aktobe, Kazakhstan Amin Tamadon amintamaddon@yahoo.com 10031947532846002157 10031947532846002157 No Department of Natural Sciences, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan