en علوم پزشکی Medical Sciences مقاله پژوهشی Original Research Article <span style="font-size:11pt"><span style="font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"><span style="font-size:10.0pt">Background and Objectives: Calprotectin is a cytosolic protein in granulocytes. Its amount in the stool is proportional to the amount of neutrophil migration from the inflamed intestinal wall to the mucous and indicates the amount of active inflammation in the mucous. It is used to help diagnose the phase of disease and the extent of colon involvement.</span></span></span><br> <span style="font-size:11pt"><span style="font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"><span style="font-size:10.0pt">Methods: For 60 patients</span> with <span style="font-size:10.0pt">ulcerative colitis (UC), who underwent colonoscopy and biopsy, 5-10 grams of stool samples were sent to Zanjan Buali&#39;s laboratory to measure calprotectin level by enzyme-linked immunosorbent assay (ELISA). The extent of colon involvement was measured by a colonoscopy exam including rectal involvement (proctitis), rectum and sigmoid (recto sigmoiditis), descending colon involvement (left side colitis), and proximal to the colon&#39;s splenic flexure (pan colitis).</span></span></span><br> <span style="font-size:11pt"><span style="font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"><span style="font-size:10.0pt">Results: All of the 60 patients who participated had UC. The average of calprotectin was 555.18&plusmn;179.41 with no significant relationship between calprotectin levels and the gender,</span> <span style="font-size:10.0pt">no significant relationship between calprotectin levels and gender, as well as between colorectal involvement and calprotectin levels. </span></span></span><br> <span style="font-size:11pt"><span style="font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"><span style="font-size:10.0pt">Conclusion: The level of fecal calprotectin may indicate the severity of colorectal involvement, but cannot show the extent of it. This inability is also present in different ages and genders. Therefore, the results say this marker cannot be used as a diagnosis of the extent of colorectal involvement in patients with UC.</span></span></span><br> &nbsp; ,Calprotectin,stool,ulcerative colitis,colonoscopy 1 7 http://modernmedlab.com/browse.php?a_code=A-10-907-2&slc_lang=en&sid=1 Hassan Neishaboori neishaboori.h@gmail.com 10031947532846002146 10031947532846002146 Yes Valiasr Hospital, Zanjan university of medical science, Zanjan, Iran Fereshteh Tamimi drfereshteht@gmail.com 10031947532846002147 10031947532846002147 No Valiasr Hospital, Zanjan university of medical science, Zanjan, Iran zeynab madani shamami zeynabm114@gmail.com 10031947532846002148 10031947532846002148 No Valiasr Hospital, Zanjan university of medical science, Zanjan, Iran Maryam Jameshorani Dr.shirinjameshorani@yahoo.com 10031947532846002149 10031947532846002149 No Valiasr Hospital, Zanjan university of medical science, Zanjan, Iran