en زیست شناسی پزشکی Medical Biology مقاله مروری Review Article <span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Colectomy is an invasive procedure indicated for various colon diseases.&nbsp; Surgical resection of the colon potentially affects glucose metabolism. The intestine secrets different hormones during digestion and controls absorption and metabolism of nutrients. There are gut-associated factors involved in glucose homeostasis. These include incretins, cholecystokinin, short-chain fatty acids, and non-esterified fatty acids. Type 2 diabetes mellitus (T2DM) is a major health problem with a constantly and dramatically increasing incidence and prevalence. In this review, the role of colon secretions and their cross-talk with gut microbiota in glucose metabolism and the pathophysiological aspects of alterations in bacterial endotoxin level, bile acid metabolism, and gut hormone secretion were highlighted. We have also noted the potential complications of colectomy in terms of glucose metabolism and homeostasis. All the clinical findings in previous studies documenting the association between T2DM post-colectomy were included as well.</span></span> Colectomy,Glucose metabolism,Type 2 diabetes mellitus,Gut microbiota 13 23 http://modernmedlab.com/browse.php?a_code=A-10-911-1&slc_lang=en&sid=1 Atena Tamimi atenatmi@gmail.com 10031947532846002158 10031947532846002158 No School of Medicine, Shahid Beheshti University of medical sciences, Tehran, Iran. Sepehr Olangian-Tehrani olangian@yahoo.com 10031947532846002159 10031947532846002159 No School of Medicine, Iran University of Medical Sciences, Tehran, Iran. Narjes Sadat Farizani Gohari Narjes.farizani@gmail.com 10031947532846002160 10031947532846002160 No Research Center of Diabetes, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. sadaf parvin sadafprv@gmail.com 10031947532846002161 10031947532846002161 No School of Medicine, Iran University of Medical Sciences, Tehran, Iran. Arash Khosravi arashkhosravi.correspondence@gmail.com 10031947532846002162 10031947532846002162 No School of Medicine, Shahid Beheshti University of medical sciences, Tehran, Iran. Zahra Khanjani Zahra.khnjni@gmail.com 10031947532846002163 10031947532846002163 No School of Medicine, Shahid Beheshti University of medical sciences, Tehran, Iran. Kiana Kimiaei Asadi Kian.a78@yahoo.com 10031947532846002164 10031947532846002164 No Hamadan University of Medical sciences, Hamadan, Iran. Seyede Fateme Saeidi Nasab Worldforever79@gmail.com 10031947532846002165 10031947532846002165 No School of Medicine, Iran University of Medical Sciences, Tehran, Iran. Kasra Moeinabadi-Bidgoli kasramoein1996@gmail.com 10031947532846002166 10031947532846002166 No Basic and Molecular Epidemiology of Gastroenterology Disorders Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Massoud Vosough masvos@Royaninstitute.org 10031947532846002167 10031947532846002167 Yes Institution for Laboratory Medicine, Karolinska Institute, Stockholm, Sweden.