en سلول های بنیادی و پزشکی بازساختی Stem Cell and Regenerative Medicine مقاله مروری Review Article <span style="font-size:12pt"><span style="line-height:150%"><span sans-serif="" style="font-family:Calibri,"><span new="" roman="" style="font-family:" times="">Dental pulp stem cells(DPSCs) are a class of stem cells which originate from dental pulp tissue and possess multiple stem cell characteristics including high clonogenicity, differentiation capacity and immunomodulatory effects.&nbsp; <span style="color:black">DPSCs can be used in different stem cell-based therapy to treat a variety of diseases, such as autoimmune, orthopedic, and neurological diseases.</span></span></span></span></span><br> <span style="font-size:12pt"><span style="line-height:150%"><span sans-serif="" style="font-family:Calibri,"><span new="" roman="" style="font-family:" times="">Recent studies showed that DPSCs combined with biomaterials provides an effective approach to craniofacial bone regeneration and reconstruction of bone defects. Scaffolds improve <span style="color:black">cell attachment, proliferation, differentiation, and migration. In the present study we discuss different combination of biomaterials with DPSCs.&nbsp; </span></span></span></span></span><br> &nbsp; ,Dental pulp stem cells,dentistry,applications,osseointegration,tissue engineering,regeneration 42 50 http://modernmedlab.com/browse.php?a_code=A-10-73-19&slc_lang=en&sid=1 Melika Zanganeh Motlagh melikazanganeh77@gmail.com 10031947532846002105 10031947532846002105 No School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran Nikoo Hossein-Khannazer nikookhannazer@gmail.com 10031947532846002106 10031947532846002106 No Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran Nazanin Mahdavi n-mahdavi@tums.ac.ir 10031947532846002107 10031947532846002107 No Department of Oral and Maxillofacial Pathology, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran Pouyan Aminishakib pouyanshakib@yahoo.com 10031947532846002108 10031947532846002108 No Department of Pathology, Cancer Institute Hospital, IKHC, Tehran University of Medical Sciences, Tehran, Iran Massoud Vosough masvos@yahoo.com 10031947532846002109 10031947532846002109 Yes Department of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran