en ایمنی شناسی Immunology مقاله مروری Review Article <span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Oral squamous cell carcinoma (OSCC) represents the most common oral cavity cancer worldwide, being among the 10 most frequent cancers of all types. Only around 50% of patients survive longer than 5 years in view of currently applied medical procedures of diagnosis and treatment. The delay in diagnosis accounts for the shortening of survival despite advances in treatment protocols. The poor prognosis as well as high occurrence rate exerts a burden on both patients and clinicians. Cancer biomarkers may possibly present cancer profiles of different patients and foreseeing each upcoming therapy response and the subsequent outcomes. Identification of the most fundamental biomarkers in OSCC may lead us to precise detection, which can give rise to earlier diagnosis, more effective treatment options, and more patient oriented prognostic decisions, alleviating the current situation regarding the failure in effectual OSCC management.&nbsp; In this review, we have outlined the molecular biomarkers for early diagnosis of OSCC and suggested inhibitors through which metastasis and its molecular pathways could potentially be inhibited.</span></span><br> &nbsp; Oral squamous cell carcinoma, biomarkers, treatment, inhibitors, molecular pathways, targeted therapy 14 25 http://modernmedlab.com/browse.php?a_code=A-10-73-9&slc_lang=en&sid=1 Melika Zangeneh Motlagh melikazangeneh77@gmail.com 10031947532846001752 10031947532846001752 No Department of oral and maxillofacial Pathology, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran Atena Tamimi atenatmi@gmail.com 10031947532846001753 10031947532846001753 No Department of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran Reihaneh Golroo ryn777rg@gmail.com 10031947532846001754 10031947532846001754 No Department of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran Nikoo Hossein-Khannazer nikookhannazer@gmail.com 10031947532846001755 10031947532846001755 No Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Pouyan Aminishakib pouyanshakib@yahoo.com 10031947532846001756 10031947532846001756 No Department of Pathology, Cancer Institute Hospital, IKHC, Tehran University of Medical Sciences, Tehran, Iran. Nazanin Mahdavi n-mahdavi@tums.ac.ir 10031947532846001757 10031947532846001757 No Department of oral and maxillofacial Pathology, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran Moustapha Hassan moustapha.hassan@ki.se 10031947532846001758 10031947532846001758 Yes Experimental Cancer Medicine, Institution for Laboratory Medicine, Karolinska Institute, Stockholm, Sweden Massoud Vosough masvos@Royaninstitute.org 10031947532846001759 10031947532846001759 No Experimental Cancer Medicine, Institution for Laboratory Medicine, Karolinska Institute, Stockholm, Sweden