Stimuli-sensitive materials-based nanocarriers: The future of cancer drug delivery!

 | Post date: 2021/08/26 | 
The smart materials for stimuli-responsive applications of drug delivery, diagnostics, theranostics, tumor imaging, and biomedical devices have obtained growing development. A major research focus is smart materials for cancer drug delivery. These smart materials are inspired to meet the demands of the booming nanocarriers that act as promising drug delivery vehicles to tumors. Because the endogenous/exogenous responsive smart materials-based nanocarriers under rational design and implementation with tumor-specific drug delivery ability can surmount their barriers during circulation or in tumors, avoiding protein corona, enzymatic degradation, cargos leakage or burst release in undesired healthy tissues, prolonging blood circulation, as well as increasing tumor accumulation, etc.
Typical stimulators applied to smart materials for cancer drug delivery include endogenous stimulators such as pH, reactive oxygen species (ROS), glutathione (GSH), hypoxia and enzyme, or exogenous stimulators such as temperature (T), light, ultrasound (US), radiation, and magnetic field.
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