An in vitro model of mammalian embryo displays extensive development of germ layer derivatives!

 | Post date: 2021/08/19 | 
Scientists at the University of Virginia Health System developed a tiny mouse embryo with a beating heart which its muscles, blood vessels, gut and nervous system are beginning to develop. This investigation which was published by Nature communications in June 2021 shows that instruction of aggregates of mouse embryonic stem cells with an experimentally engineered morphogen signalling centre, that functions as an organizer, results in the development of embryo-like entities (embryoids). In situ hybridization, immunolabelling, cell tracking and transcriptomic analyses show that these embryoids form the three germ layers through a gastrulation process and that they exhibit a wide range of developmental structures, highly similar to neurula-stage mouse embryos.
This in vitro model is not a complete mouse yet and cannot develop into one due to the fact that Key parts are still missing, such as the anterior part of the brain. However, this embryoid will help scientists understand mammalian development, battle diseases, create new drugs and, eventually, grow tissues and organs for people in need of transplants.
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