Modern Medical Laboratory Journal

The outbreak of novel coronavirus disease 2019 (COVID-19) has become a major pandemic threat worldwide. According to the existing clinical data, this virus not only causes respiratory diseases and affects the lungs but also induces histopathological or functional changes in various organs of a nonrespiratory system, such as the kidney, liver, brain, heart, testis and also the male genital tract. SARS-CoV-2 was found in semen analysis of male patients and like many other viruses, such as mumps, hepatitis, herpes simplex, influenza, and human immunodeficiency viruses (HIV), it could infect the testis, the male genital tract and cause damage to male fertility. The renin-angiotensin system (RAS), also ACE 2 and TMPRSS2 play an important role in the cellular entry for SARS-CoV-2. Because the male genital system presents high ACE 2 expression, the importance of this pathway increases in COVID-19 cases. 
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