Substrate stiffness and topography: two powerful means for the modulation of MSCs activities!

 | Post date: 2021/06/14 | 
Substrate stiffness and topography are two powerful means by which mesenchymal stem cells (MSCs) activities can be modulated. These two physical cues act simultaneously to regulate cellular function in vessel wall. Hence it is important to investigate their cooperative effects on cellular activity. In a study conducted in 2019, the combined effects of substrate stiffness, substrate topography and culture time on the mechanical behavior of MSCs were investigated. 
Results of this study indicated that substrate topography significantly interacted with substrate stiffness as well as culture time in the modulation of cell viscoelastic behavior and smooth muscle (SM) gene expression.  According to this investigation, The micro-grooved, stiff substrates resulted in the maximum cell stiffness and gene expression of α-actin and h1-calponin, and these values were detected to be minimum in the smooth, soft substrates. 
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