Stress and Cancer: Is there any relationship?

 | Post date: 2022/03/25 | 
The notion that stress and cancer are interlinked has dominated lay discourse for decades. More recent animal studies indicate that stress can substantially facilitate cancer progression through modulating most hallmarks of cancer, and molecular and systemic mechanisms mediating these effects have been elucidated. However, available clinical evidence for such deleterious effects is inconsistent, as epidemiological and stress-reducing clinical interventions have yielded mixed effects on cancer mortality. 
The best quality clinical studies have followed up many people for several years. They have found no evidence that those who are more stressed are more likely to get cancer. However, it should be noted that animal studies leverage their ability to synchronize stress exposure with specific phases of cancer growth and metastasis that are critically prone to stress. By contrast, epidemiological studies and most clinical trials assessing stress-reducing psychosocial interventions did not focus on stress-prone phases, some of which cannot be identified and addressed clinically.
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