Modern Medical Laboratory Journal
Mod Med Lab J
Medical Sciences
http://modernmedlab.com
1
admin
2371-770X
2371-770X
10.30699/mmlj17
en
jalali
1399
10
1
gregorian
2021
1
1
4
1
online
1
fulltext
en
Representing Tumor-Associated Macrophages as the Angiogenesis and Tumor Microenvironment Regulator
ایمنی شناسی
Immunology
مقاله مروری
Review Article
Over the recent years, studies in the area of cancer microenvironment and the cellular groups existing in this environment have indicated the significant role of them in progression of cancer studies. Among the mentioned cellular groups, as the main inflammatory components of stroma, Tumor associate macrophage (TAM) cells have the capacity of affecting the cancer tissue in different aspects. With their plasticity capacity, macrophages can change into M1 (classic) or M2 (alternative) macrophage reacting to different signals. In the tumor environment, they usually change into the M2 phenotype, and this phenotype can create a precancerous role in the macrophage and facilitate the invasion of tumor cells and metastasis, angiogenesis, remodeling of the extracellular matrix, and suppression of the immune system. The various roles of these cells and their reversibility have made the TAMs a potential target of the cancer treatment. This process takes place by different mechanisms such as Interference with TAMs survival, Inhibition of macrophage recruitment, repolarization of M2-like TAMs towards an M1-like phenotype, nano particle and liposome-based drug delivery system. This review study investigates the markers and the function of M1, M2, and tumor-associated macrophages, and finally, it proposes the latest clinical and laboratory approach for targeting the TAMs.
tumor associated macrophage, inflammation, angiogenesis, immunosuppression, TAM-based therapy
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67
http://modernmedlab.com/browse.php?a_code=A-10-73-3&slc_lang=en&sid=1
Erfan
Mohammadi Sepahvand
erfan.msepah94@gmail.com
10031947532846001517
10031947532846001517
No
Faculty of Veterinary Medicine, Karaj Branch, Islamic Azad University, Karaj, Iran
Mina
Masoudnia
masoudnia.mina@yahoo.com
10031947532846001518
10031947532846001518
No
Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Haniyeh
Sadat Hosseininia
hanahosseininia75@gmail.com
10031947532846001519
10031947532846001519
No
Department of Cellular and Molecular Biology, Faculty of Advanced Medical Science, Tehran Islamic Azad University of Medical Sciences, Tehran, Iran
Alireza
Kazempour
ali42153@gmail.com
10031947532846001520
10031947532846001520
No
Department of Microbiology, Faculty of Science, Lahijan Branch, Islamic Azad University, Lahijan, Iran
Nazila
Bostanshirin
n.bostan@abzums.ac.ir
10031947532846001521
10031947532846001521
No
Department of Microbiology, School of Medicine Science, Alborz University of Medical Science, Alborz, Iran
Arsalan
Jalili
Jalili.arsalan@royaninstitute.org
10031947532846001522
10031947532846001522
Yes
Hematopoietic Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Amin
Ebrahimi Sadrabadi
Amin.ebrahimi@royaninstitute.org
10031947532846001523
10031947532846001523
No
Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACER, Tehran, Iran.