Modern Medical Laboratory Journal
Mod Med Lab J
Medical Sciences
http://modernmedlab.com
1
admin
2371-770X
2371-770X
10.30699/mmlj17
en
jalali
1399
3
1
gregorian
2020
6
1
3
2
online
1
fulltext
en
اثر متقابل ویروس انسانی پاپیلوما ویروس (E6 ،E7) و پروتئین رتینوبلاستوما (pRb) در رگ زایی
The Interaction of Human Papilloma Virus Oncoproteins (E6,E7) and Retinoblastoma Protein (pRb) in Angiogenesis
Regulation
بیماری های عفونی
Infectious Diseases
مقاله مروری
Review Article
Cervical cancer is a type of cancer that occurs in the squamous cells of the uterus. Different types of Human Papilloma Virus (HPV), a sexual infection, play a key role in endometrial cancer. It has double-stranded DNA with a genome composed of 8000 base pairs and it is classified into two types of low risk and high risk, and it seems that two 16 and 18 high-risk strains are responsible for more than 70% of endometrial cancer cases and they only host those human cells which may not be obvious clinically or they may cause benign and malignant lesions. This type of cancer depends on two E6, and E7 oncoproteins that play role in formation of tumor structurally and angiogenesis compared to other important factors that have a significant role in the progression of this type of cancer. The present study aims to investigate the performance of two E6 and E7 oncogenes and their inhibitory activity in line with suppressing P53 and PRB and also investigating the role of angiogenesis in the function of these oncogenes
Cervical cancer, HPV, E6 and E7, PRB, Angiogenesis
74
82
http://modernmedlab.com/browse.php?a_code=A-10-79-3&slc_lang=en&sid=1
Nazli
balazadeh Yamchlou
Nazli
Alibalazadeh Yamchlou
jalili.arsalan@yahoo.com
10031947532846001467
10031947532846001467
No
Department of Molecular and Cellular Sciences, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
Atyieh
Soleymani
Atyieh
Soleymani
jalili.arsalan@yahoo.com
10031947532846001468
10031947532846001468
No
Department of Molecular and Cellular Sciences, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
Arsalan
Jalili
Arsalan
Jalili
jalili.arsalan@yahoo.com
10031947532846001469
10031947532846001469
Yes
Hematopoietic Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Amin
Ebrahimi Sadrabadi
Amin
Ebrahimi Sadrabadi
Amin.ebrahimi@royaninstitute.org
10031947532846001470
10031947532846001470
No
Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACER, Tehran, Iran