Modern Medical Laboratory Journal
Mod Med Lab J
Medical Sciences
http://modernmedlab.com
1
admin
2371-770X
2371-770X
10.30699/mmlj17
en
jalali
1397
3
1
gregorian
2018
6
1
1
2
online
1
fulltext
en
The Cytotoxic Effects of Eggplant Peel Extract on Human Gastric Adenocarcinoma Cells and Normal Cells
بیوشیمی پزشکی
Medical Biochemistry
مقاله پژوهشی
Original Research Article
<p dir="ltr" style="text-align: justify"><em><strong>Background and objective: </strong></em>Gastric cancer is the fourth common and the second deadliest cancer worldwide, which the major causes of its prevalence are genetic factors and the lifestyle, such as eating fast foods, physical inactivity, environmental pollution, and other natural factors.</p>
<p dir="ltr" style="text-align: justify"><em><strong>Method: </strong></em>This research was performed in human and animal cell bank of Iranian Biological Resource Center, and cytotoxic effects of the eggplant peel extract was investigated on human gastric cancer cells and normal cells. During this experiment, all quality control procedures were performed on cell lines, including bacteria, fungi, yeasts, molds, mycoplasma, as well as HIV-I, HBV, HCV, EBV viruses, and the results of negative tests were reported. MTT test was used to determine the cytotoxicity of this substance and the IC50 value.</p>
<p dir="ltr" style="text-align: justify"><em><strong>Resutls: </strong></em>The results indicated that the toxic effect of eggplant extract was more on the cancer cells compared to the normal cells and it is notable that, the death rate of the cancer cells in three concentrations showed a significant difference compared to the normal cells. </p>
<p dir="ltr" style="text-align: justify"><em><strong>Conclusion: </strong></em>From the results of this study, it is recommended that further investigations be conducted on eggplant extract as an anticancer nutrient.</p>
Eggplant, Antioxidant, Cancer, MTT assay
77
83
http://modernmedlab.com/browse.php?a_code=A-10-1-22&slc_lang=en&sid=1
Fatemeh
Afshari
10031947532846001591
10031947532846001591
No
Jahad-e Daneshgahi, National center for genetic and biological resources of Iran, bank of human and animal cells, Tehran, Iran
Hoda
Seraj
10031947532846001592
10031947532846001592
No
Jahad-e Daneshgahi, National center for genetic and biological resources of Iran, bank of human and animal cells, Tehran, Iran
Zahra
Sadat Hashemi
10031947532846001593
10031947532846001593
No
Jahad-e Daneshgahi, National center for genetic and biological resources of Iran, bank of human and animal cells, Tehran, Iran
Marziyeh
Timajchi
10031947532846001594
10031947532846001594
No
Rah-e Shayestegan, Tehran, Iran
Olamafar
Ensiyeh
10031947532846001595
10031947532846001595
No
Rah-e Shayestegan, Tehran, Iran
Ghotbi
Ladan
10031947532846001596
10031947532846001596
No
Rah-e Shayestegan, Tehran, Iran
Masoomeh
Asadi
10031947532846001597
10031947532846001597
No
Jahad-e Daneshgahi, National center for genetic and biological resources of Iran, bank of human and animal cells, Tehran, Iran
Zahra
Elyasi
10031947532846001598
10031947532846001598
No
Jahad-e Daneshgahi, National center for genetic and biological resources of Iran, bank of human and animal cells, Tehran, Iran
Meysam
Ganjibakhsh
meysam_ganjy@yahoo.com
10031947532846001599
10031947532846001599
Yes
Jahad-e Daneshgahi, National center for genetic and biological resources of Iran, bank of human and animal cells, Tehran, Iran