en بیوشیمی پزشکی Medical Biochemistry مقاله مروری Review Article <span style="font-size:11pt"><span new="" roman="" style="font-family:" times=""><span style="font-size:10.0pt">Colistin relates to the polymyxin group of antibiotics. This antibiotic is still used to destroy gram-negative bacteria as a last resort. However, resistance to this antibiotic has been reported and is appearing day by day. Not much information is available on the exact mechanisms of resistance to this antibiotic. Also, not enough information about pharmacokinetics and pharmacodynamics is available, so the optimal dose should be determined to use these antibiotics to prevent the toxic effects of this antibiotic. In current study, additionally to their pharmacokinetics and pharmacodynamics, we have presented current knowledge about the genes and two-component systems that may cause such resistance to polymyxin and colistin.</span></span></span><br> <br> &nbsp; Colistin, Polymyxin, gram-negative bacteria, Resistance mechanism 1 18 http://modernmedlab.com/browse.php?a_code=A-10-73-13&slc_lang=en&sid=1 Morteza Sedaghat mr.morteza@live.com 10031947532846001993 10031947532846001993 Yes Department of Cellular and Molecular Biology, University of Kashan, Kashan, Iran Elahe Mahmoodi Khaledi e.mahmoodi_kh@kashanu.ac.ir 10031947532846001994 10031947532846001994 No Department of Cellular and Molecular Biology, University of Kashan, Kashan, Iran